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    You may experience symptoms of allergy (hives, rash, swelling face and tongue) and also chest pain or heavy feeling, sudden numbness or weakness, abnormal vaginal bleeding, migraine headache, confusion, jaundice, swelling in hands, ankles, or feet. If such symptoms are severe stop taking this medication and notify your doctor at once.
    Premarin is a mixture of estrogen hormones which regulates development and functions of female reproductive system, formation of female secondary sex characteristics. On entering into the bloodstream it forms a complex with a specific receptor (in the fallopian tubes, cervix, excretory ducts of the mammary glands, vagina, urethra, breast, liver, hypothalamus, hypophisis), stimulates synthesis of DNA and proteins. It results in proliferation of the epithelium, increased sensitivity of the uterus and tubes muscles of to medications stimulatign their motility. This medication decreases bone resorption of Ca2 + in menopause, prevents involution of the genitals. Premarin is used to treat symptoms of menopause which include hot flashes, vaginal dryness, vaginal irritation and dryness, to prevent osteoporosis in postmenopausal women. Replacement therapy in peri- and postmenopausal women, ovarian hypofunction (primary and secondary amenorrhea, oligomenorrhea, dysmenorrhea) and other conditions.
    Inform your doctor of your entire medical history, including: diabetes, asthma, epilepsy, high blood pressure, migraines, liver or kidney disease, heart strokes, depression, toxemia, jaundice during pregnancy, excessive fluid retention and weight gain during menstruation, uterine fibroid tumor, abnormal vaginal bleeding, gallbladder disease, cholesterol, lipid problems or blood clots. Provide information on your family medical history too, especially of breast cancer and lumps.
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    Premarin can interact with blood thinners (warfarin), barbiturates, rifampin, phenytoin, carbamazepine, griseofulvin, St. John’s wort, erythromycin, ketonazole, ritonavir and primidone.Take the missed dose as soon as possible. If it is almost time of the next intake just skip it and go back to your schedule.
    Pregnant women and persons under 18 y.o. can’t use the Premarin. Be careful using the medicine for long-term treatment. It can increase risk of breast cancer, endometrial hyperplasia, heart attack, or stroke

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